Efficacy of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) in hepatocellular carcinoma with macrovascular invasion: a single-center retrospective analysis

Table 4 Comparative analysis of liver volume changes after the both stages of ALPPS procedure for three hepatocellular carcinoma patient groups

	P-HCC	PVTT-HCC	HVTT-HCC	F/X ² value	P value
The first stage of ALPPS
SLV, cm ³	1052.9 ± 121.0	1058.8 ± 118.5	1069.1 ± 92.2	0.073	0.929
FLR, cm³	363.8 ± 97.7	404.6 ± 85.0	411.4 ± 66.3	2.428	0.094
FLR/SLV, %	34.5 ± 7.6	38.3 ± 7.6	38.8 ± 7.6	2.995	0.055
GRWR	0.59 ± 0.13	0.65 ± 0.13	0.66 ± 0.15	2.706	0.073
The second stage of ALPPS
SLV, cm³	1036.9 ± 101.7	1044.9 ± 117.2	1059.9 ± 79.3	0.154	0.857
FLR, cm³	556.4 ± 109.2	587.5 ± 132.3	565.2 ± 82.1	0.632	0.534
FLR/SLV	53.7 ± 9.4	56.5 ± 12.4	53.3 ± 6.4	0.703	0.489
GRWR	0.92 ± 0.17	0.97 ± 0.23	0.89 ± 0.11	0.721	0.490
Variation of GRWR between the two stages of ALPPS	0.33(0.07–0.72)	0.25(0.05–0.78)	0.33(0.03–0.43)	0.331	0.847
Times between the two stages of ALPPS, days	11(3–50)	13(5-174)	9(7-141)	4.294	0.117
Absolute proliferation of FLR, cm³	211.0 ± 92.3	186.7 ± 96.5	167.4 ± 98.9	0.512	0.601
Relative proliferation rate of FLR, %	19.4(3.6–42.1)	14.8(2.7–42.3)	20.5(1.3–25.4)	0.429	0.807
KGR, %	13.7(1.6–71.6)	7.8(0.6–35.3)	13.1(0.7–25.4)	2.256	0.324

Abbreviations: P-HCC, pure hepatocellular carcinoma; PVTT-HCC, portal vein tumor thrombus hepatocellular carcinoma; HVTT-HCC, hepatic vein tumor thrombus hepatocellular carcinoma. ALPPS, association liver partition and portal vein ligation for staged hepatectomy; SLV, standard liver volume; FLR, future liver remnant; GRWR, graft-to-recipient weight ratio; KGR, kinetic growth rate

ISSN: 1477-7819