Table 2 Performance characteristics of cytology, molecular, and parallel analysis in definitive diagnosis of malignancy from thyroid nodules
From: BRAF V600E mutation in thyroid carcinoma: a large-scale study in Han Chinese population
Diagnostic modality | Sensitivity, % | Specificity, % | Positive predictive value,% | Negative predictive value,% | AUC |
|---|---|---|---|---|---|
BRAF testing | 85.5 (84.3–86.6) | 100 (84.5–100) | 100 (99.9–100) | 4.6 (3.1–6.7) | 0.927 (0.910–0.945) |
FNA analysis | 97.6 (97.0–98.0) | 81.5 (61.3–93.0) | 99.9 (99.7–100.0) | 18.8 (12.4–27.3) | 0.895 (0.809–0.982) |
BRAF testing in FNA indeterminate cytology | 72.5 (60.2–82.2) | 100 (79.1–100) | 100 (91.1–100) | 50 (33.7–66.3) | 0.862 (0.809–0.915) |
Parallel analysis | 99.3 (99.0–99.5) | 81.5 (61.3–93.0) | 99.9 (99.7–100.0) | 44.9 (30.9–59.7) | 0.904 (0.817–0.991) |