Fig. 3

Cellular composition of TLS. (A, B, C) IT-TLS, IM-TLS, and PT-TLS all demonstrate that TLS are predominantly comprised of CD20 + B lymphocytes, with relatively fewer CD4 + T lymphocytes and CD8 + T lymphocytes present. Foxp3 + T regulatory cells and NK cells are relatively rare within TLS. (D) There is no significant difference in the quantity of CD20 + B cells among IT-TLS, IM-TLS, and PT-TLS. (E) Compared to PT-TLS, IT-TLS and IM-TLS exhibit a higher number of CD8 + T cells, with statistical significance (P < 0.05). (F) There is no significant difference in the number of CD4 + T cells between IT-TLS, IM-TLS, and PT-TLS. (G) There is no significant difference in the number of Foxp3 + Treg cells among IT-TLS, IM-TLS, and PT-TLS. (H) There is no significant difference in the number of CD56 + NK cells between IT-TLS, IM-TLS, and PT-TLS