Table 1 Relationship among TLS, PD-L1(22C3) and clinical pathological features in 33 patients with TLS + primary adenocarcinoma of jejunum and ileum
Clinical pathological features | Cases | TLS density | P value | IT-TLS density | P value | IM-TLS density | P value | PT-TLS density | P value | E-TLS density | P value | PEL-TLS density | P value | SFL-TLS density | P value | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
High | Low | High | Low | High | Low | High | Low | High | Low | High | Low | High | Low | ||||||||||
Age(y) | ≤ 60 | 20 | 11 | 9 | 0.728 | 11 | 9 | 0.728 | 12 | 8 | 0.276 | 11 | 9 | 0.728 | 9 | 11 | 0.481 | 10 | 10 | 1.000 | 12 | 8 | 0.296 |
>60 | 13 | 6 | 7 | 6 | 7 | 5 | 8 | 6 | 7 | 8 | 5 | 7 | 6 | 5 | 8 | ||||||||
sex | M | 19 | 10 | 9 | 1.000 | 8 | 11 | 0.296 | 9 | 10 | 0.728 | 11 | 8 | 0.491 | 9 | 10 | 0.728 | 10 | 9 | 1.000 | 11 | 8 | 0.491 |
F | 14 | 7 | 7 | 9 | 5 | 8 | 6 | 6 | 8 | 8 | 6 | 7 | 7 | 6 | 8 | ||||||||
Tumor site | Jejunum | 27 | 15 | 12 | 0.398 | 14 | 13 | 1.000 | 15 | 12 | 0.398 | 15 | 12 | 0.398 | 15 | 12 | 0.398 | 14 | 13 | 1.000 | 12 | 15 | 0.175 |
Ileum | 6 | 2 | 4 | 3 | 3 | 2 | 4 | 2 | 4 | 2 | 4 | 3 | 3 | 5 | 1 | ||||||||
Tumor size(cm) | ≤ 5 | 23 | 12 | 11 | 1.000 | 13 | 10 | 0.465 | 12 | 11 | 1.000 | 10 | 13 | 0.259 | 13 | 10 | 0.465 | 14 | 9 | 0.141 | 10 | 13 | 0.259 |
>5 | 10 | 5 | 5 | 4 | 6 | 5 | 5 | 7 | 3 | 4 | 6 | 3 | 7 | 7 | 3 | ||||||||
Macroscopic tumor perforation | Yes | 2 | 1 | 1 | 1.000 | 2 | 0 | 0.485 | 1 | 1 | 1.000 | 1 | 1 | 1.000 | 2 | 0 | 0.485 | 0 | 2 | 0.227 | 0 | 2 | 0.227 |
No | 31 | 16 | 15 | 15 | 16 | 16 | 15 | 16 | 15 | 15 | 16 | 17 | 14 | 17 | 14 | ||||||||
Differentiation grade | Moderately differentiation | 22 | 12 | 10 | 1.000 | 13 | 9 | 0.698 | 12 | 10 | 1.000 | 12 | 10 | 0.682 | 11 | 11 | 1.000 | 12 | 10 | 0.682 | 12 | 10 | 0.682 |
Poorly differentiation | 8 | 4 | 4 | 4 | 4 | 4 | 4 | 3 | 5 | 4 | 4 | 3 | 5 | 3 | 8 | ||||||||
Lymphatic invasion | Yes | 21 | 9 | 12 | 0.282 | 11 | 10 | 1.000 | 11 | 10 | 1.000 | 10 | 11 | 0.721 | 11 | 10 | 1.000 | 10 | 11 | 0.721 | 11 | 10 | 1.000 |
No | 12 | 8 | 4 | 6 | 6 | 6 | 6 | 7 | 5 | 6 | 6 | 7 | 5 | 6 | 6 | ||||||||
Vascular invasion | Yes | 10 | 3 | 7 | 0.141 | 3 | 7 | 0.141 | 4 | 6 | 0.465 | 3 | 7 | 0.141 | 4 | 6 | 0.465 | 5 | 5 | 1.000 | 5 | 5 | 1.000 |
No | 23 | 14 | 9 | 14 | 9 | 13 | 10 | 14 | 9 | 13 | 10 | 12 | 11 | 12 | 11 | ||||||||
Neural invasion | Yes | 22 | 10 | 12 | 0.465 | 12 | 10 | 0.727 | 13 | 9 | 0.282 | 11 | 11 | 1.000 | 11 | 11 | 1.000 | 13 | 9 | 0.282 | 10 | 12 | 0.465 |
No | 11 | 7 | 4 | 5 | 6 | 4 | 7 | 6 | 5 | 6 | 5 | 4 | 7 | 7 | 4 | ||||||||
Tumor nodules | Yes | 11 | 4 | 7 | 0.282 | 3 | 8 | 0.071 | 4 | 7 | 0.282 | 3 | 8 | 0.071 | 6 | 5 | 1.000 | 5 | 6 | 0.721 | 6 | 5 | 1.000 |
No | 22 | 13 | 9 | 14 | 8 | 13 | 9 | 14 | 8 | 11 | 11 | 12 | 10 | 11 | 11 | ||||||||
Mucinous component | Yes | 7 | 2 | 5 | 0.225 | 1 | 6 | 0.039 | 2 | 5 | 0.225 | 3 | 4 | 0.688 | 4 | 3 | 1.000 | 4 | 3 | 1.000 | 4 | 3 | 1.000 |
No | 26 | 15 | 11 | 16 | 10 | 15 | 11 | 14 | 12 | 13 | 13 | 13 | 13 | 13 | 13 | ||||||||
T stage | T3 | 12 | 9 | 3 | 0.071 | 8 | 4 | 0.282 | 7 | 5 | 0.721 | 7 | 5 | 0.721 | 7 | 5 | 0.721 | 4 | 8 | 0.157 | 6 | 6 | 1.000 |
T4 | 21 | 8 | 13 | 9 | 12 | 10 | 11 | 10 | 11 | 10 | 11 | 13 | 8 | 11 | 10 | ||||||||
N stage | N0 | 22 | 12 | 10 | 0.721 | 12 | 10 | 0.721 | 13 | 9 | 0.282 | 13 | 9 | 0.282 | 12 | 10 | 0.721 | 12 | 10 | 0.721 | 11 | 11 | 1.000 |
N1-3 | 11 | 5 | 6 | 5 | 6 | 4 | 7 | 4 | 7 | 5 | 6 | 5 | 6 | 6 | 5 | ||||||||
M stage | M0 | 16 | 10 | 6 | 0.303 | 8 | 8 | 1.000 | 8 | 8 | 1.000 | 11 | 5 | 0.084 | 7 | 9 | 0.494 | 10 | 6 | 0.303 | 8 | 8 | 1.000 |
M1 | 17 | 7 | 10 | 9 | 8 | 9 | 8 | 6 | 11 | 10 | 7 | 7 | 10 | 9 | 8 | ||||||||
TNM stage | II | 12 | 7 | 5 | 0.721 | 6 | 6 | 1.000 | 7 | 5 | 0.721 | 8 | 4 | 0.282 | 6 | 6 | 1.000 | 7 | 5 | 0.721 | 6 | 6 | 1.000 |
III-IV | 21 | 10 | 11 | 11 | 10 | 10 | 11 | 9 | 12 | 11 | 10 | 10 | 11 | 11 | 10 | ||||||||
PD-L1(22C3) | CPS ≥ 1 | 11 | 6 | 5 | 1.000 | 5 | 6 | 0.721 | 3 | 8 | 0.071 | 8 | 3 | 0.141 | 4 | 7 | 0.282 | 7 | 4 | 0.465 | 6 | 5 | 1.000 |
CPS<1 | 22 | 11 | 11 | 12 | 10 | 14 | 8 | 9 | 13 | 13 | 9 | 10 | 12 | 11 | 11 | ||||||||
MSI-H | Yes | 3 | 2 | 1 | 1.000 | 1 | 2 | 0.601 | 15 | 15 | 1.000 | 2 | 1 | 1.000 | 1 | 2 | 0.601 | 1 | 2 | 0.601 | 2 | 1 | 1.000 |
No | 30 | 15 | 15 | 16 | 14 | 2 | 1 | 15 | 15 | 16 | 14 | 16 | 14 | 15 | 15 | ||||||||
TMB | High | 12 | 9 | 3 | 0.073 | 6 | 6 | 1.000 | 6 | 6 | 1.000 | 8 | 4 | 0.282 | 5 | 7 | 0.481 | 7 | 5 | 0.721 | 6 | 6 | 1.000 |
Low | 21 | 8 | 13 | 11 | 10 | 11 | 10 | 9 | 12 | 12 | 9 | 10 | 11 | 11 | 10 | ||||||||
KRAS mutation | Yes | 17 | 9 | 8 | 1.000 | 9 | 8 | 1.000 | 11 | 6 | 0.169 | 10 | 7 | 0.494 | 10 | 7 | 0.494 | 10 | 7 | 0.494 | 8 | 9 | 0.732 |
No | 16 | 8 | 8 | 8 | 8 | 6 | 10 | 7 | 9 | 7 | 9 | 7 | 9 | 9 | 7 | ||||||||
BRAF mutation | Yes | 31 | 16 | 15 | 1.000 | 15 | 16 | 0.485 | 17 | 14 | 0.227 | 16 | 15 | 1.000 | 16 | 15 | 1.000 | 16 | 15 | 1.000 | 16 | 15 | 1.000 |
No | 2 | 1 | 1 | 2 | 0 | 0 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||
PIK3CA mutation | Yes | 1 | 1 | 0 | 1.000 | 1 | 0 | 1.000 | 1 | 0 | 0.515 | 1 | 0 | 1.000 | 0 | 1 | 0.485 | 0 | 1 | 0.485 | 1 | 0 | 1.000 |
No | 32 | 16 | 16 | 16 | 16 | 16 | 16 | 16 | 16 | 17 | 15 | 17 | 15 | 16 | 16 | ||||||||