Table 1 Patients’ demographics and clinical characteristics

Variables

2158

1435

723

Sex (%)

 Male

1553 (72.0)

1111 (77.4)

442 (61.1)

< 0.001

 Female

605 (28.0)

324 (22.6)

281 (38.9)

 Age (mean (SD))

58.72 (9.90)

60.06 (9.41)

56.07 (10.31)

< 0.001

 BMI (mean (SD))

22.70 (3.20)

22.84 (3.21)

22.43 (3.15)

0.004

pTNM (%)

 I

427 (19.8)

338 (23.6)

89 (12.3)

< 0.001

 II

646 (29.9)

461 (32.1)

185 (25.6)

 III

1005 (46.6)

594 (41.4)

411 (56.8)

 IV

80 (3.7)

42 (2.9)

38 (5.3)

Borrmann (%)

 0

298 (13.8)

234 (16.3)

64 (8.9)

< 0.001

 I

76 (3.5)

58 (4.0)

18 (2.5)

 II

423 (19.6)

322 (22.4)

101 (14.0)

 III

1194 (55.3)

775 (54.0)

419 (58.0)

 IV

167 (7.7)

46 (3.2)

121 (16.7)

LVI (%)

 Negative

1037 (48.1)

722 (50.3)

315 (43.6)

0.004

 Positive

1121 (51.9)

713 (49.7)

408 (56.4)

PNI (%)

 Negative

666 (30.9)

520 (36.2)

146 (20.2)

< 0.001

 Positive

1492 (69.1)

915 (63.8)

577 (79.8)

HER2 (%)

 0

1203 (55.7)

664 (46.3)

539 (74.6)

< 0.001

 1+

572 (26.5)

428 (29.8)

144 (19.9)

 2+

251 (11.6)

219 (15.3)

32 (4.4)

 3+

132 (6.1)

124 (8.6)

8 (1.1)

Chemotherapy (%)

 No

1114 (51.6)

774 (53.9)

340 (47.0)

0.003

 Yes

1044 (48.4)

661 (46.1)

383 (53.0)

Location (%)

 Low

1413 (65.5)

985 (68.6)

428 (59.2)

< 0.001

 Middle

437 (20.3)

269 (18.7)

168 (23.2)

 Upper

197 (9.1)

140 (9.8)

57 (7.9)

 Whole

111 (5.1)

41 (2.9)

70 (9.7)

 Tumor size (mean (SD))

47.85 (25.12)

46.03 (23.60)

51.48 (27.54)

< 0.001

 LYM (mean (SD))

1.99 (0.68)

2.02 (0.70)

1.94 (0.62)

0.012

 LDH (mean (SD))

160.19 (38.68)

160.40 (41.69)

159.78 (31.88)

0.723

 PALB (mean (SD))

250.18 (72.14)

249.66 (74.76)

251.20 (66.68)

0.64

 K (mean (SD))

4.26 (0.42)

4.28 (0.43)

4.22 (0.40)

0.001

 CA199 (mean (SD))

43.98 (130.67)

44.82 (133.83)

42.30 (124.24)

0.673

 CA125 (mean (SD))

13.15 (14.18)

13.24 (15.11)

12.99 (12.14)

0.703