The diagnostic accuracy of urine-derived exosomes for bladder cancer: a systematic review and meta-analysis

Table 4 Summary estimates of diagnostic efcacy for exosomal profling in bladder cancer detection

Analysis		SEN(95% CI)	SPE(95% CI)	PLR(95% CI)	NLR(95% CI)	DOR(95% CI)	AUC(95% CI)
Exosomal ncRNA types	lncRNA	0.78	0.75	3.13	0.29	10.72	0.83
	miRNA	0.69	0.81	3.63	0.38	9.6	0.83
	mRNA	0.69	0.79	3.34	0.39	8.63	0.81
Ethnicity	Asian	0.75	0.77	3.28	0.32	10.24	0.83
Ethnicity	Caucasian	0.73	0.78	3.29	0.35	9.50	0.82
Sample size	＞100	0.74	0.76	3.14	0.34	9.35	0.82
Sample size	≤100	0.75	0.78	3.51	0.31	11.22	0.84
Exosome extraction methods	Exosome isolation kit	0.78	0.76	3.29	0.29	11.50	0.84
Exosome extraction methods	ultracentrifugation	0.70	0.79	3.33	0.37	8.89	0.82
Exosomal panels	Single exosomes	0.73	0.76	3.04	0.35	8.59	0.81
Exosomal panels	Multiple exosomes	0.79	0.80	4.04	0.26	15.80	0.87
Overall	/	0.75	0.77	3.28	0.33	10.04	0.83

CI confdence interval, SEN sensitivity, SPE specifcity, PLR positive likelihood ratio, NLR negative likelihood ratio, DOR diagnostic odds ratio, AUC area under the curve

ISSN: 1477-7819