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Table 1 Main characteristics of studies included in meta-analysis

From: Pan-immune-inflammation value as a novel prognostic biomarker for digestive system cancers: a meta-analysis

Author(year)

Study region

Study design

Sample size

Study period

Cancer type

Sampling time

Cutoff values

Outcomes, HR estimation

Analysis method

Treatment strategy

Quality score

Fucà G (2020)

Italy

retrospective

438

2008–2018

Colorectal cancer

Before treatment

380

OS, 1.55(1.02–2.37)

PFS, 1.53 (1.09–2.15)

U/M

Chemotherapy; Target therapy

8

Baba Y (2021) (Validation )

Japan

retrospective

433

2005–2020

Esophageal cancer

Within 1 week before treatment

164.6

OS, 1.37 (1.02–1.85)

U/M

Surgery

8

Baba Y (2021) (Derivation )

OS, 1.63(1.22–2.19)

U

Surgery

7

Corti F (2021)

Italy

retrospective

163

2014–2020

Colorectal cancer

Within 1 week before treatment

492

OS, 3.21 (1.65–6.23)

PFS, 2.25 (1.30–3.89)

U/M

Immunotherapy

8

KaradaÄŸ I (2022)

Turkey

retrospective

120

2013–2021

Hepatocellular cancer

Before treatment

286.15

OS, 1.813 (1.119–2.938)

M

Mixed therapy

7

Pérez-Martelo M (2022)

Spain

retrospective

130

2015–2018

Colorectal cancer

Within 1 month before treatment

380

OS, 1.823(1.146–2.898)

PFS, 1.561(1.054–2.311)

U/M

Chemotherapy

8

Sato S (2022)

Japan

retrospective

758

2000–2019

Colorectal cancer

Before treatment

376

OS, 2.485(1.552–3.981)

RFS, 1.697(1.097–2.624)

U/M

Surgery

8

Topkan E (2022)

Turkey

retrospective

178

2007–2020

Pancreatic adenocarcinoma

Before treatment

464

OS, 2.86(2.58–3.14)

PFS, 3.04(2.87–3.21)

M

Chemoradiotherapy

7

Wang SB (2022)

China

retrospective

89

2010–2018

Gastric cancer

Before treatment

218.7

DFS, 1.611 (0.795–3.264)

U

Surgery

6

Efil SC (2023)

Turkey

retrospective

304

2008–2016

Colorectal cancer

Within 2 weeks before treatment

491

OS, 2.44(1.55–3.82)

DFS, 2.28(1.50–3.45)

U

Surgery

7

Feng J (2023)

China

retrospective

294

2013–2014

Esophageal Cancer

Within 1 week before treatment

308.2

CSS, 1.983 (1.475–2.664)

U/M

Surgery

7

Feng J (2023)

China

retrospective

218

2019–2021

Esophageal Cancer

Before treatment

373.6

OS, 2.364 (1.183–4.724)

DFS, 1.729 (1.026–2.913)

U/M

Surgery

8

Qi WX (2023)

China

retrospective

51

2019–2022

Esophageal Cancer

Before treatment

232.8

PFS, 2.08(0.68–6.25)

U

Chemoradiotherapy; Target therapy

6

Sato R (2023)

Japan

retrospective

86

2013–2020

Colorectal cancer

Before treatment

209

RFS, 3.99(1.69–9.45)

CSS, 3.41(1.12–10.38)

M

Surgery

7

Wang HK (2023)

China

retrospective

356

2013–2019

Esophageal Cancer

Within 1 week before treatment

178.055

OS, 4.099(1.127–14.902)

U/M

Surgery

8

Yeh CC (2023)

China

retrospective

853

2005–2017

Oral cavity carcinoma

Before treatment

268

OS, 1.281(1.027–1.596)

DFS, 1.165(0.943–1.438)

U/M

Surgery

8

Fu M (2024)

China

retrospective

84

2018–2023

Gastric cancer

Within 1 week before treatment

499.08

OS, 0.56(0.05–6.55)

U

Immunotherapy

7

Fu M (2024)

China

retrospective

107

2019–2023

Esophageal Cancer

Within 1 week before treatment

415.885

OS, 2.35(1.31–4.20)

U

Immunotherapy

7

Liu Q (2024)

China

retrospective

172

2018–2019

Colorectal cancer

Before treatment

265.75

OS, 2.476(1.410–4.348)

U/M

Surgery

8

Seo YJ (2024)

Korea

retrospective

203

2016–2020

Colorectal cancer

2 days before the surgery

155.90

OS, 8.363(1.028–68.016)

DFS, 2.215 (0.596–8.235)

M

Surgery

7

  1. HR hazard ration; OS overall survival; PFS progression-free survival; DFS disease-free survival; RFS recurrence-free survival; CSS cancer-specific survival; U univariate analysis; M multivariate analysis