Table 2 Subgroup analyses of PIV and OS in digestive system cancers
Categories | Studies (patients) | HR (95% CI) | I2 (%)* | Ph* | Z | P | |
|---|---|---|---|---|---|---|---|
Cancer type | Digestive tract Cancer | 14(4652) | 1.689(1.504–1.896) | 49.5 | 0.018 | 8.88 | < 0.001 |
Colorectal cancer | 7(2168) | 2.178(1.786–2.657) | 10.5 | 0.349 | 7.68 | < 0.001 | |
Esophageal cancer | 5(1547) | 1.656(1.373–1.996) | 31.8 | 0.209 | 5.29 | < 0.001 | |
Hepatobiliary pancreatic cancer | 2(298) | 2.427(1.581–3.727) | 69.9 | 0.070 | 4.05 | < 0.001 | |
Analysis method | Multivariate analysis | 12(4022) | 2.076(1.578–2.732) | 83.4 | < 0.001 | 5.22 | < 0.001 |
Univariate analysis | 13(4449) | 2.630(1.700-4.068) | 94.1 | < 0.001 | 4.34 | < 0.001 | |
Sampling time | Within 1 week before treatment | 7(1779) | 1.960(1.411–2.724) | 48.3 | 0.071 | 4.01 | < 0.001 |
Before treatment | 9(3171) | 2.042(1.539–2.708) | 84.1 | < 0.001 | 4.95 | < 0.001 | |
Cutoff values | < 300 | 7(2570) | 1.631(1.304–2.039) | 46.3 | 0.083 | 4.29 | < 0.001 |
≥ 300 | 9(2380) | 2.692(2.466–2.937) | 39.7 | 0.103 | 22.20 | < 0.001 | |
Sample size | < 300 | 9(1375) | 2.741(2.505–2.999) | 20.1 | 0.264 | 21.96 | < 0.001 |
≥ 300 | 7(3575) | 1.686(1.359–2.092) | 55.8 | 0.035 | 4.75 | < 0.001 | |
Treatment strategy | Surgery | 9(3730) | 1.885(1.484–2.394) | 59.1 | 0.012 | 5.20 | < 0.001 |
Chemotherapy/Target therapy/Immunotherapy/Radiotherapy | 6(1100) | 2.237(1.656–3.023) | 60.9 | 0.025 | 5.24 | < 0.001 | |
Study region | East Asia | 10(3617) | 1.828(1.450–2.304) | 51.8 | 0.028 | 5.10 | < 0.001 |
Other region | 6(1333) | 2.230(1.723–2.887) | 63.7 | 0.017 | 6.09 | < 0.001 | |