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Table 2 Logistic regression analysis of the risk factors for VTE in the training cohort

From: Development and validation of a nomogram for predicting venous thromboembolism risk in post-surgery patients with cervical cancer

Groups

Training cohort (n = 822)

No-VTE

(n = 760)

VTE

(n = 62)

Univariable

[OR(95%CI, P)]

Multivariate

[OR(95%CI, P)]

Age(ys)

52.90 ± 10.98

52.43 ± 10.39

58.63 ± 15.62

1.05 (1.03–1.07, < 0.001)

1.04 (1.02–1.07, < 0.001)

BMI (%)

 18.5–23.9

467 (56.81)

433 (56.97)

34 (54.84)

  

 24–27.9

219 (26.64)

204 (26.84)

15 (24.19)

0.94 (0.50–1.76, 0.838)

 

 ≥ 28

79 (9.61)

72 (9.47)

7 (11.29)

1.24 (0.53–2.90, 0.623)

 

 < 18.5

57 (6.93)

51 (6.71)

6 (9.68)

1.50 (0.60–3.74, 0.387)

 

Marriage (%)

 Married

739 (89.90)

687 (90.39)

52 (83.87)

  

 Others

83 (10.10)

73 (9.61)

10 (16.13)

1.81 (0.88–3.71, 0.106)

 

Pathologictype (%)

 SCC

727 (88.44)

679 (89.34)

48 (77.42)

  

 Adenocarcinoma/others

95 (11.56)

81 (10.66)

14 (22.58)

2.44 (1.29–4.63, 0.006)

3.28 (1.56–6.92, 0.002)

FIGO stage (%)

 I-II

553 (67.27)

527 (69.34)

26 (41.94)

  

 III-IV

269 (32.73)

233 (30.66)

36 (58.06)

3.13 (1.85–5.31, < 0.001)

1.92 (1.06–3.48, 0.032)

Surgerytypes (%)

 Open surgery

303 (36.86)

278 (36.58)

25 (40.32)

  

 Laparoscopic surgery

497 (60.46)

461 (60.66)

36 (58.06)

0.87 (0.51–1.48, 0.603)

 

 Robotic surgery

22 (2.68)

21 (2.76)

1 (1.61)

0.53 (0.07–4.10, 0.543)

 

Radiotherapy (%)

 NO

503 (61.19)

480 (63.16)

23 (37.10)

  

 YES

319 (38.81)

280 (36.84)

39 (62.90)

2.91 (1.70–4.97, < 0.001)

 

Chemotherapy (%)

 NO

498 (60.58)

475 (62.50)

23 (37.10)

  

 YES

324 (39.42)

285 (37.50)

39 (62.90)

2.83 (1.65–4.83, < 0.001)

2.69 (1.47–4.89, 0.001)

Targetedtherapy (%)

 NO

784 (95.38)

727 (95.66)

57 (91.94)

  

 YES

38 (4.62)

33 (4.34)

5 (8.06)

1.93 (0.73–5.14, 0.187)

 

Immunotherapy (%)

 NO

814 (99.03)

754 (99.21)

60 (96.77)

  

 YES

8 (0.97)

6 (0.79)

2 (3.23)

4.19 (0.83–21.20, 0.083)

 

WBC (10*9/L,%)

 ≤ 10

771 (93.80)

716 (94.21)

55 (88.71)

  

 > 10

51 (6.20)

44 (5.79)

7 (11.29)

2.07 (0.89–4.81, 0.091)

 

PLT (10*9/L,%)

     

 ≤ 300

676 (82.24)

627 (82.50)

49 (79.03)

  

 > 300

146 (17.76)

133 (17.50)

13 (20.97)

1.25 (0.66–2.37, 0.493)

 

D-dimer (mg/L,%)

 ≤ 0.5

528 (64.23)

516 (67.89)

12 (19.35)

  

 > 0.5

294 (35.77)

244 (32.11)

50 (80.65)

8.81 (4.61–16.85, < 0.001)

4.57 (2.23–9.36, < 0.001)

PT (sec)

11.00 ± 1.01

11.00 (0.99)

11.04 (1.21)

1.05 (0.81–1.35, 0.728)

 

APTT(sec)

26.86 ± 3.47

26.85 (3.37)

26.94 (4.55)

1.01 (0.94–1.08, 0.850)

 

FIB (g/L)

3.16 ± 1.00

3.11 (0.94)

3.78 (1.40)

1.67 (1.36–2.05, < 0.001)

 

FDP(ug/ml)

3.05 ± 3.98

2.76 (3.58)

6.62 (6.36)

1.17 (1.10–1.23, < 0.001)

1.08 (1.02–1.16, 0.016)

Microglobulin(mg/L)

2.40 ± 1.41

2.34 ± 1.33

3.20 ± 1.96

1.27 (1.11–1.46, < 0.001)

 

NLR

3.58 ± 3.59

3.38 ± 3.21

6.03 ± 6.19

1.12 (1.07–1.17, < 0.001)

1.07 (1.01–1.13, 0.017)

Surgerytime(min)

115.81 ± 74.94

117.32 ± 75.63

97.19 ± 63.58

1.00 (0.99–1.00, 0.043)

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