Fig. 4

Characteristics of myeloid cells in EOCC and LOCC. (A-C) t-SNE plots of all myeloid cells, color-coded by cluster (A), cell type (B), and group (C). (D) Bubble plots illustrating the expression levels of marker genes across different myeloid subpopulations. (E) Pie charts showing the proportions of myeloid subpopulations within each group. (F) Bubble plots displaying significantly enriched KEGG pathways of DEGs between EOCC and LOCC derived myeloid cells. (G) Violin plots comparing immune-related gene set scores in macrophages between EOCC and LOCC. (H) Violin plots demonstrating differential expression of immune-related molecules in macrophages between EOCC and LOCC. (I) Violin plots showing differentially expressed HLA in DC cells between EOCC and LOCC. Significance levels: *, p-value < 0.05; **, p-value < 0.01; ***, p-value < 0.001; ****, p-value < 0.0001