Table 4 Diagnostic accuracy data from nine studies of exosomal biomarkers
From: Systematic review and meta-analysis: diagnostic accuracy of exosomes in pancreatic cancer
First author | Biomarker name | Type | Sen (%) | Spe (%) | PLR | NLR | DOR |
|---|---|---|---|---|---|---|---|
Haruki Odaka | CD63+-EVs | Platelet-derived EVs | 0.821 | 0.846 | 5.33 | 0.21 | 25.20 |
CD41+-EVs | Platelet-derived EVs | 0.718 | 0.744 | 2.80 | 0.38 | 7.40 | |
CD61+-EVs | Platelet-derived EVs | 0.718 | 0.641 | 2.00 | 0.44 | 4.55 | |
CD63+-EVs & CA19-9 | Platelet-derived EVs | 0.897 | 0.872 | 7.01 | 0.12 | 59.33 | |
Sonia A. Melo | GPC1+ crExos | Cell surface proteoglycan | 1.000 | 1.000 | / | 0.00 | / |
Juan Li | LRG1-Exos | Cell surface proteoglycan | 0.743 | 0.933 | 11.09 | 0.28 | 40.48 |
GPC1-Exos | Cell surface proteoglycan | 0.800 | 0.933 | 11.94 | 0.21 | 26.14 | |
LRG1-Exos & GPC1-Exos | Cell surface proteoglycan | 0.914 | 0.867 | 6.87 | 0.10 | 69.46 | |
Lu Hong | hsa_circ_0006220 | Exosomal circular RNA | 0.774 | 0.726 | 2.82 | 0.31 | 9.08 |
hsa_circ_0001666 | Exosomal circular RNA | 0.968 | 0.516 | 2.00 | 0.06 | 31.95 | |
hsa_circ_0006220 & hsa_circ_0001666 | Exosomal circular RNA | 0.742 | 0.871 | 5.75 | 0.30 | 19.42 | |
P. Moutinho-Ribeiro | GPC1+crExos | Cell surface proteoglycan | 0.983 | 0.862 | 7.12 | 0.02 | 361.19 |
Jia Chen | miR-451a | exomiR | 0.801 | 0.867 | 6.01 | 0.23 | 26.17 |
Yusuke Yoshioka | GPRC5C+EV | G protein-coupled receptor | 0.519 | 0.889 | 4.68 | 0.54 | 8.64 |
EPS8+EV | Epidermal growth factor | 0.667 | 0.833 | 3.99 | 0.40 | 9.99 | |
Zhiguo Yu | GPC1+EV | Cell surface proteoglycan | 1.000 | 0.909 | 10.99 | 0.00 | / |
Takashi Taniguchi | MicroRNA-20a | exomiR | 0.820 | 0.860 | 5.86 | 0.21 | 27.98 |