Fig. 1
From: Diagnostic utility of LEF1 and β-catenin in WNT pathway tumors with CTNNB1 mutation
A Morphology of BA (A1, H&E staining, original magnification ×100). Tumor cells exhibited focal membranous and nuclear/cytoplasmic positivity for β-catenin (A2, ×200). LEF1 expression was characterized by nuclear staining, mainly located in peripheral myoepithelial cells, with weaker staining in central cell nests (A3, ×200). B Morphology of DF originating from the nasal cavity (B1, H&E, original magnification ×100). β-catenin immunostaining revealed a cytoplasmic dotted-like pattern. (B2, ×200). Tumor cells were positive for LEF1 immunostaining (B3, ×200). C Morphology of DF (C1, H&E, original magnification ×100). Tumors showed strong and diffuse β-catenin nuclear/cytoplasmic labeling (C2, ×200). LEF1 immunostaining was negative (C3, ×200). D Morphology of SPN (D1, H&E, original magnification ×100). Tumors showed a diffuse β-catenin nuclear pattern along with cytoplasmic staining (D2, ×200). LEF1 nuclear staining showed no immunoreaction for normal pancreatic tissue (D3, ×200). E Morphology of BA (E1, H&E, original magnification ×100). Tumors showed a β-catenin membranous pattern (E2, ×200; The upper right corner showed magnification ×400). LEF1 nuclear staining was identified (E3, ×200). F Morphology of SPN (F1, H&E, original magnification ×100; The upper right corner showed magnification ×400). Tumors showed a β-catenin membranous pattern (F2, ×200; The upper right corner showed magnification ×400). LEF1 nuclear staining was observed (F3, ×200)