Table 3 Predictive factors for occult endometrial carcinoma in patients with endometrioid intraepithelial neoplasia who underwent hysterectomy
Variables | ECA N (%) | OR (95% CI) | P value | aOR (95% CI) | P value |
|---|---|---|---|---|---|
Age, y | |||||
< 50, n = 64 | 23 (35.9) | Reference | 0.289 | ||
≥ 50, n = 49 | 13 (26.9) | 0.644 (0.285–1.453) | |||
BMI (kg/m2) | |||||
≤ 30, n = 63 | 15 (23.8) | Reference | 0.041 | ||
> 30, n = 50 | 21 (42.0) | 2.317 (1.034–5.194) | |||
< 23, n = 25 | 7 (28.0) | Reference | 0.639 | ||
≥ 23, n = 88 | 29 (33.0) | 1.264 (0.475–3.367) | |||
Parity | |||||
Multiparous, n = 56 | 13 (22.8) | Reference | |||
Nulliparous, n = 57 | 23 (41.1) | 1.801 (1.017–3.189) | 0.037 | ||
Menopausal status | |||||
Premenopausal, n = 83 | 29 (34.9) | Reference | 0.242 | ||
Postmenopausal, n = 33 | 7 (23.3) | 0.567 (0.217–1.478) | |||
Diabetes mellitus | |||||
No, n = 96 | 30 (31.3) | Reference | 0.742 | ||
Yes, n = 17 | 6 (35.3) | 1.200 (0.406–3.549) | |||
Hypertension | |||||
No, n = 87 | 26 (29.9) | Reference | 0.412 | ||
Yes, n = 26 | 10 (38.5) | 1.466 (0.588–3.657) | |||
Endometrium thickness | |||||
< 2 cm, n = 36 | 9 (25.0) | Reference | 0.236 | ||
≥ 2 cm, n = 34 | 13 (38.2) | 1.857 (0.667–5.168) | |||
Endometrial biopsy methods | |||||
FC/hysteroscopy, n = 51 | 11 (21.6) | Reference | 0.036 | Reference | 0.032 |
ES, n = 62 | 25 (40.3) | 2.457 (1.063–5.682) | 2.752 (1.092–6.936) | ||
Intraoperative gross lesion | |||||
No gross lesion, n = 56 | 10 (17.9) | Reference | Reference | ||
Gross lesion < 2, n = 38 | 15 (39.5) | 3.867 (1.320-11.327) | 0.014 | 3.381 (1.128–10.132) | 0.030 |
Gross lesion ≥ 2, n = 19 | 11 (57.9) | 5.977 (2.264–16.503) | 0.001 | 6.723 (2.338–19.333) | < 0.001 |