Table 4 Cox proportional regression analysis for predictors of disease-free survival
Parameter | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
HR (95% CI) | P-value | HR (95% CI) | P-value | |
Gender | 0.957 | |||
Female | Ref | |||
Male | 0.98(0.47–2.01) | |||
Age at diagnosis | 0.841 | |||
≤ 57 years | Ref | |||
> 57 years | 0.93(0.43–1.84) | |||
BMI | ||||
< 18.5 | Ref | |||
18.5–29.9 | 0.66(0.19–2.19) | 0.499 | ||
≥ 30 | 0.37(0.08–1.70) | 0.204 | ||
Comorbidities | 0.394 | |||
No | Ref | |||
Yes | 1.35(0.67–2.70) | |||
Adjuvant (Post-operative chemotherapy) | 0.783 | |||
No | Ref | |||
Yes | 0.90(0.45–1.79) | |||
PCI | < 0.001 | |||
≤ 6 | Ref | Ref | ||
> 6 | 4.44(2.17–9.11) | 3.4(1.44- 8.00) | 0.005 | |
CC | 0.01 | |||
0 | Ref | |||
1 | 4.27(1.40–12.9) | |||
Postoperative complications | ||||
No | Ref | |||
Yes | 2.18(0.98–4.86) | 0.056 | ||
Length of hospital stay | 0.207 | |||
≤ 21 days | Ref | |||
> 21 days | 1.55(0.78–3.11) | |||
Tumor type | ||||
Intestinal | Ref | |||
Adenocarcinoma | 2.97(0.81–10.77) | 0.097 | ||
Diffuse | 1.88(0.85–4.12) | 0.114 | ||
mixed | 0.97(0.27–3.54) | 0.975 | ||
Tumor location | ||||
GEJ junction | Ref | Ref | ||
antrum | 0.35(0.12–0.96) | 0.043 | 0.28(0.14–0.88) | 0.03 |
body | 0.30(0.03–2.36) | 0.255 | ||
cardia | 0.39(0.08–1.83) | 0.234 | ||
overlapping location | 1.90(0.68–5.28) | 0.213 | ||
fundus | 1.02(0.22–4.67) | 0.979 | ||
pylorus | 0.63(0.21–1.87) | 0.416 | ||
Surgery type | ||||
-Radical total gastrectomy with D2 lymphadenectomy | Ref | Ref | ||
- Subtotal esophagectomy and total gastrectomy with D2 lymphadenectomy and colon interposition | ||||
3.43(1.52–7.75) | 0.003 | 2.94(1.05–8.28) | 0.04 | |
Signet sign | ||||
Absent | Ref | |||
Present | 1.25(0.63–2.50) | 0.512 | ||
Staging | ||||
Stage 1a/b- 3a/b/c | Ref | |||
Stage 4 | 3.13(1.52 6.42) | 0.002 | ||
Resection Margin | ||||
Negative | Ref | |||
Positive | 2.15(0.92- 5.00) | 0.074 | ||
Lymphovascular invasion | ||||
Absent | Ref | |||
Present | 2.37(1.19–4.73) | 0.014 | ||
Perineural invasion | ||||
Absent | Ref | Ref | ||
Present | 2.55(1.26–5.16) | 0.009 | 3.02(1.28–7.11) | 0.012 |
Her 2 neu expression | ||||
Negative | Ref | |||
Positive | 0.94(0.40–2.18) | 0.895 | ||
Clavien-dindo ≥ III | ||||
No | Ref | Ref | ||
Yes | 2.98 (1.49–5.96) | 0.002 | 2.66 (1.15–6.13) | 0.021 |