Table 5 Cox proportional regression analysis for predictors of disease-free survival
Parameter | Univariable analysis | Multivariable analysis | ||
|---|---|---|---|---|
HR (95% CI) | P-value* | HR (95% CI) | P-value† | |
Gender | ||||
Female | Ref | |||
Male | 1.50(0.62–3.63) | 0.36 | ||
Age at diagnosis | 0.98(0.96–1.01) | 0.366 | ||
BMI | ||||
< 18.5 | Ref | |||
18.5–29.9 | 0.87(0.20–3.75) | 0.861 | ||
≥30 | 0.42(0.06–2.56) | 0.35 | ||
Comorbidities | ||||
No | Ref | |||
Yes | 0.72(0.32–1.60) | 0.43 | ||
Adjuvant (Post-operative chemotherapy) | ||||
No | ||||
Yes | Ref | |||
0.83(0.38–1.79) | 0.64 | |||
pPCI | ||||
≤ 6 | Ref | < 0.001 | Ref | |
> 6 | 5.20(2.18–12.42) | 4.56 (1.81–11.45) | 0.001< | |
CC | ||||
CC0 | Ref | |||
CC1 | 4.55(1.28–16.2) | 0.019 | ||
Postoperative complications | ||||
No | Ref | |||
Yes | 0.92(0.42–2.01) | 0.837 | ||
Length of hospital stay | 1.00(0.99- 1.00) | 0.702 | ||
Tumor type | ||||
Intestinal | Ref | |||
Adenocarcinoma | 0.97(0.12–7.59) | 0.979 | ||
Diffuse | 1.25(0.53–2.91) | 0.603 | ||
mixed | 0.91(0.25–3.32) | 0.896 | ||
Tumor location | ||||
GEJ junction | Ref | |||
antrum | 0.48(0.16–1.42) | 0.188 | ||
body | 0.96(0.20–4.66) | 0.966 | ||
cardia | 0.48(0.09–2.45) | 0.385 | ||
overlapping location | 0.93(0.19–4.49) | 0.929 | ||
fundus | 2.99(0.76–11.69) | 0.115 | ||
pylorus | 0.51(0.13–1.99) | 0.337 | ||
Surgery type | ||||
-Radical total gastrectomy with D2 lymphadenectomy | Ref | |||
- Subtotal esophagectomy and total gastrectomy with D2 lymphadenectomy and colon interposition | ||||
0.81(0.27–5.09) | 0.779 | |||
Signet sign | ||||
Absent | Ref | 0.833 | ||
Present | 0.91(0.42- 2.00) | |||
Staging | ||||
Stage 1a/b- 3a/b/c | Ref | |||
Stage 4 | 2.39(1.05–5.40) | 0.036 | ||
Pathologic T stage | ||||
T0 | Ref | |||
T1a/b- T2 | 0.30(0.04–1.82) | 0.192 | ||
T3- T4a/b | 1.14(0.26–4.90) | 0.857 | ||
Pathologic N stage | ||||
N0-N1 | Ref | |||
N2-N3a/b | 3.09(1.41–6.80) | 0.005 | ||
Pathologic M stage | ||||
M0 | Ref | |||
M1 | 2.02(0.91–4.45) | 0.082 | ||
Resection Margin | ||||
Negative | Ref | |||
Positive | 1.91(0.71–5.14) | 0.195 | ||
Lymphovascular invasion | ||||
Absent | Ref | |||
Present | 2.18(1.00- 4.77) | 0.049 | ||
Perineural invasion | ||||
Absent | Ref | |||
Present | 1.78(0.82–3.86) | 0.142 | ||
Her 2 neu expression | ||||
Negative | Ref | |||
Positive | 1.72(0.74–3.99) | 0.203 | ||
Clavien-dindo ≥ III | ||||
No | Ref | |||
Yes | 0.55(0.16–1.84) | 0.337 |