Table 3 Pathological features between gene mutation status. p value was calculated compared with reference group using χ2 test (p < 0.05: *, p < 0.01: **, p < 0.001: ***). STAS: spread through air space
From: Gene mutation, clinical characteristics and pathology in resectable lung adenocarcinoma
|  | EGFR +  | EGFR- | p | ALK fusion +  | ALK fusion- | p | KRAS +  | KRAS- | p |
|---|---|---|---|---|---|---|---|---|---|
pleura invasion | |||||||||
 yes | 75 | 104 |  | 13 | 164 | ** | 12 | 165 |  |
 no | 468 | 474 |  | 25 | 919 |  | 62 | 882 |  |
carcinothrombosis | |||||||||
 yes | 13 | 19 |  | 3 | 28 |  | 4 | 26 |  |
 no | 530 | 559 |  | 35 | 1055 |  | 70 | 1021 |  |
STAS | |||||||||
 yes | 19 | 33 |  | 8 | 46 | *** | 11 | 42 | *** |
 no | 524 | 545 |  | 30 | 1037 |  | 63 | 1005 |  |
lepidic | |||||||||
 yes | 169 | 42 | *** | 3 | 208 |  | 6 | 205 | * |
 no | 375 | 536 |  | 35 | 876 |  | 68 | 843 |  |
solid | |||||||||
 yes | 39 | 40 |  | 9 | 70 | *** | 11 | 68 | * |
 no | 505 | 538 |  | 29 | 1014 |  | 63 | 980 |  |
micropapillary | |||||||||
 yes | 37 | 30 | * | 9 | 58 | *** | 4 | 63 |  |
 no | 507 | 548 |  | 29 | 1026 |  | 70 | 985 |  |