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Table 2 First-line treatment and efficacy after SCLC transformation

From: Patients outcomes in lung adenocarcinoma transforming to small-cell lung cancer after tyrosine kinase inhibitor therapy

First line therapy after transformation

Cases (n)

Median PFS (95%CI, m)

Median OS since diagnosed (95%CI, m)

Platinum + etoposide

46

3.0 m (2.05 to 3.95 m)

42.7 m (31.61 to 53.79 m)

Platinum + etoposide + TKI

19

3.2 m (2.21 to 4.19 m)

59.3 m

Others

21

5.0 m (3.42 to 6.58 m)

37.0 m (24.45 to 49.55 m)

Total

86

4.0 m (3.43 to 4.57 m)

40.0 m (33.97 to 46.03 m)

  1. Abbreviations: SCLC Small cell lung cancer, TKI Tyrosine kinase inhibitor, PFS Progression-free survival, OS Overall survival