Fig. 6

Silencing EDN1 inhibited tumor growth of mice. A, The tumor size in each group; B, Tumor weight in each group; C, H&E and IHC assays were performed to assess the pathological status of tumor tissue and the protein levels of EDN1, Ki67, and TNFR1 in each group. (n = 10; ***p < 0.001 vs. A549 + sh-NC group; ###p < 0.001 vs. A549/DDP + sh-NC group). H&E, hematoxylin-eosin; sh-RNA, short hairpin RNA; IHC, immunohistochemistry; TNFR1, tumor necrosis factor receptor-1; DDP, cisplatin