Fig. 2

Representative patients with (A-D) apparent radiological shrinkage of the main tumor (patient #19), (E-H) presence of spread through air spaces (patient #24), and (I-L) presence of pathological complete response (patient #16)

(A-D) Computed tomographic (CT) scan revealed a marked decrease of tumor size (yellow squares) and apparent shrinkage of mediastinal lymph nodes (red squares) after Erlotinib plus Bevacizumab treatment. Evident left pulmonary hilum invasion by tumor was also shown (red arrow) (see Supplemental Video 1). (E-H) CT scan revealed marked reduction of tumor size after Afatinib treatment. Pathologic examination showed spread through air spaces, with tumor cells in air spaces beyond the edge of the main tumor. (I-L) CT scan revealed marked decrease of tumor size after Osimertinib treatment. Pathologic examination showed extensive fibrosis and inflammation without viable tumor cells in the tumor bed area, indicating the pathological complete response. (Hematoxylin and eosin stain; G and L: original magnification x40; H: original magnification x200.)