Table 3 Multivariate HRs for OS after surgery by the Three-gene score and the other risk factors

score

score 1

vs. score 0

2.09 (1.46–2.97)

p < 0.001

score 2

vs. score 0

3.08 (2.01–4.73)

p < 0.001

vs. score 1

1.48 (1.02–2.14)

P = 0.038

score 3

vs. score 0

9.01 (3.49–23.31)

p < 0.001

vs. score 1

4.32 (1.71–10.90)

P = 0.002

vs. score 2

2.92 (1.13–7.55)

p = 0.027

Primary lymph node metastases

1.63 (1.17–2.28)

p = 0.004

Number of CRLM, >1

1.67 (1.14–2.45)

p = 0.009

Response to chemotherapy

PR

Reference

no preoperative chemotherapy

0.77 (0.44–1.32)

p = 0.338

SD

1.45 (1.04–2.02)

p = 0.027

PD

2.94 (1.63–5.31)

p < 0.001

Major hepatectomy

1.59 (1.13–2.23)

p = 0.007