Table 5 Subgroup analyses of overall cancer risk in patients on dialysis
From: Incidence of major urological cancers in patients on dialysis: a systematic review and meta-analysis
Characteristic | All cancers except NMSC | Kidney cancers | Bladder cancers | Prostate cancers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SIRs (95% CI) | Heterogeneity | SIRs (95% CI) | Heterogeneity | SIRs (95% CI) | Heterogeneity | SIRs (95% CI) | Heterogeneity | ||||||
I2 (%) | P-valuea | I2 (%) | P-valuea | I2 (%) | P-valuea | I2 (%) | P-valuea | ||||||
Ethnicity | Asian | 1.54 (1.33–1.78) | 45 | 0.178 | 8.22 (3.58–18.87) | 85.6 | 0.008 | 2.75 (1.67–4.53) | 0 | 0.71 | 0.27 (0.10–0.73) | 0 | 0.971 |
Non-Asian | 1.37 (1.23–1.53) | 95.5 | <0.001 | 4.30 (3.59–5.14) | 96 | <0.001 | 1.83 (1.56–2.15) | 92.6 | <0.001 | 0.97 (0.82–1.15) | 93.4 | <0.001 | |
Gender | Men | 1.37(1.21–1.56) | 86.6 | <0.001 | 2.66 (2.01–3.51) | 0 | 0.803 | 1.48 (1.22–1.81) | 0 | 0.606 | 0.94 (0.79–1.11) | 92.1 | <0.001 |
Women | 1.48(1.30–1.68) | 94.1 | <0.001 | 4.98 (2.32–10.67) | 63.6 | 0.064 | 4.19 (2.14–8.22) | 57 | 0.127 | NA | NA | NA | |
Age | 0–34 | 4.09(2.59–6.47) | 93 | <0.001 | 38.04 (18.46–78.39) | 86 | 0.001 | 16.26 (5.27–50.19) | 84.4 | 0.002 | NA | NA | NA |
35–64 | 1.88(1.41–2.50) | 96.9 | <0.001 | 5.50 (4.20–7.21) | 94 | <0.001 | 2.59 (1.66–4.06) | 97.6 | <0.001 | NA | NA | NA | |
>64 | 1.21(1.11–1.32) | 78.2 | 0.003 | 3.07 (2.10–4.49) | 90.3 | <0.001 | 1.37 (1.07–1.75) | 86.1 | 0.001 | NA | NA | NA | |
Follow-up time (years) | 1 | 2.16 (1.53–3.04) | 99 | <0.001 | 8.16 (4.45–14.96) | 96.8 | <0.001 | 2.33 (1.47–3.67) | 95.4 | <0.001 | NA | NA | NA |
2 | 1.47 (1.22–1.77) | 95.4 | <0.001 | 3.97 (2.87–5.50) | 74.4 | 0.004 | 1.51 (1.36–1.67) | 0 | 0.58 | NA | NA | NA | |
3–5 | 1.32 (1.07–1.63) | 96.8 | <0.001 | 4.15 (2.94–5.86) | 86.9 | <0.001 | 1.92 (1.29–2.86) | 92.7 | <0.001 | NA | NA | NA | |
>5 | 1.03 (0.81–1.30) | 96.9 | <0.001 | 6.29 (3.74–10.58) | 77.8 | 0.001 | 1.91 (0.96–3.79) | 93.6 | <0.001 | NA | NA | NA | |
Primary renal disease | Diabetic nephropathy | 1.07 (0.88–1.31) | 94.2 | <0.001 | 2.07 (1.36–3.16) | 70.9 | 0.016 | 0.89 (0.77–1.03) | 0 | 0.472 | NA | NA | NA |
Glomerulon-ephritis | 1.53 (1.34–1.75) | 87.3 | <0.001 | 5.03 (3.52–7.18) | 87.3 | 0.001 | 1.43 (0.82–2.49) | 87.3 | <0.001 | NA | NA | NA | |
Hypertensive & arteriopathy | 1.35 (0.78–2.34) | 93.2 | <0.001 | 3.44 (2.18–5.44) | 83.5 | <0.001 | 1.76 (1.03-3.00) | 92 | <0.001 | NA | NA | NA | |
All other and unknown | 1.53 (1.23–1.90) | 67.7 | 0.026 | 6.56 (3.90-11.05) | 58.0 | 0.068 | 2.38 (1.61–3.50) | 0 | 0.446 | NA | NA | NA | |