Fig. 8

DCC-2036 inhibits the growth of xenografted 143B cells in BALB/C-nude mice a, Representative images of subcutaneous tumor size in mice at the conclusion of the experiment (upper panel) alongside a statistical chart of tumor volume (lower panel). b, Subcutaneous tumor growth curve of 143B cells in BALB/C-nude mice, where 2 × 10^6 cells mixed with Matrigel were xenografted subcutaneously into BALB/C-nude mice. The tumor volume (in mm³) was measured one week later (upper panel). Additionally, body weight curves of BALB/C-nude mice throughout the experiment are presented (lower panel). c, Representative images of hematoxylin and eosin (HE) staining, as well as immunohistochemical staining for p-HCK, HCK, P62, and LC3B expression. d, Immunoblotting was conducted on xenografted tumor tissues following the experiment, with tumor tissues selected randomly