Table 3 Subgroup analysis results of meta-analysis
From: Meta-analysis of the diagnostic value of SOX1 methylation in different types of cervical cancer
Subgroup | No. of studies | Sen(95%CI) | I²(%) | Spe(95%CI) | I²(%) | PLR(95%CI) | I²(%) | NLR(95%CI) | I²(%) | DOR(95%CI) | I²(%) | AUC |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sample size < 200 | 13 | 0.84 (0.81–0.87) | 22.40 | 0.87 (0.85–0.89) | 87.50 | 6.48 (4.02–10.44) | 82.70 | 0.19 (0.16–0.23) | 0.0 | 41.03 (22.26–75.61) | 58.20 | 0.90 |
Sample size ≥ 200 | 5 | 0.91 (0.87–0.93) | 74.60 | 0.75 (0.72–0.77) | 98.60 | 3.91 (2.15–7.14) | 96.20 | 0.11 (0.05–0.23) | 74.60 | 62.08 (15.07-255.66) | 84.20 | 0.97 |
Cervical tissue | 9 | 0.87 (0.84–0.90) | 59.80 | 0.64 (0.60–0.68) | 91.80 | 3.36 (1.98–5.69) | 86.40 | 0.17 (0.13–0.22) | 0.0 | 23.01 (15.25–34.71) | 38.20 | 0.91 |
Cervical cell | 9 | 0.86 (0.83–0.89) | 59.10 | 0.85 (0.83–0.87) | 96.30 | 10.12 (4.85–21.12) | 95.30 | 0.17 (0.11–0.24) | 54.10 | 72.24 (31.46-165.86) | 73.80 | 0.94 |
With precancerous lesions | 9 | 0.86 (0.83–0.89) | 70.10 | 0.74 (0.72–0.76) | 95.00 | 4.58 (3.11–6.76) | 93.80 | 0.18 (0.14–0.22) | 40.70 | 28.83 (20.79-40.00) | 3.60 | 0.91 |
Without precancerous lesions | 9 | 0.88 (0.84–0.90) | 29.30 | 0.96 (0.94–0.97) | 92.10 | 16.82 (4.25–66.53) | 91.90 | 0.13 (0.09–0.17) | 33.30 | 161.22 (27.51-944.83) | 82.50 | 0.94 |