Fig. 2

Characterization of epithelial cell populations in pancreatic cancer. A t-SNE plot illustrating the segmentation of epithelial cells, with distinct colors representing various cell types; the left plot corresponds to metastatic cancer, while the right plot represents carcinoma in situ. B Stacked bar graph displaying the proportion of cells within each group. C Left panel: Graphs depicting the dynamic expression patterns of representative differentially expressed genes (DEGs) across epithelial cell populations. Middle panel: Heatmap highlighting representative DEGs between cell clusters. Right panel: Representative enriched gene ontology (GO) terms for each cell cluster