Fig. 5

Construction and validation processes of the risk models. A Depicted the coefficient distributions derived from log(λ) sequences in the LASSO models. B LASSO coefficient spectrum for LASSO cox analysis. C Forest plot of multivariate Cox regression analysis. HR is the risk ratio. D Training centralized models to predict 1-year, 3-year, and 5-year AUC curves for risk models. All AUC > 0.6. E Compared the survival curves for overall survival between the high-risk and low-risk groups within the training set. F Plot of the distribution of survival status and risk group scores in the training set. G GSE20685 validates the 1- , 3- , and 5-year AUC curves predicted by the centralized model. All AUC > 0.6. (H) GSE20685 validated survival curves for overall survival. I Distribution of survival status and distribution of risk group scores in the GSE20685 validation set. (J) GSE42568 validates the 1-, 3-, and 5- year AUC curves predicted by the model. The AUCs are all > 0.7. K Survival curves for overall survival in GSE42568 validation, (L) Distribution of GSE42568 validation centralized survival status and distribution of risk group scores. (M) K-M curves of characterized genes CD24, EPB41L4B, IL12B, NT5E, and SORBS1 (P < 0.05)