Table 3 Risk of recurrence within 3 years* estimated by Cox proportional hazard ratio model

Age:

 < 65 years

ref.

 ≥ 65 years

1.039 (0.846–1.276)

Sex:

 Male

1.036 (0.844–1.273)

 Female

ref.

Neoadjuvant chemo:

 Yes

1.323 (1.031–1.699)

1.319 (1.019–1.708)

0.036

 No

ref.

Any complication:

 Yes

1.081 (0.877–1.333)

 No

ref.

Severe complication:

 Yes

1.037 (0.765–1.406)

 No complication

ref.

 Not in analysis (C-D 1-3a)

Duration of surgery:

 < 480 min

ref.

 ≥ 480 min

1.117 (0.910–1.370)

Postop leukopenia:

 Yes

0.962 (0.676–1.369)

0.890 (0.586–1.351)

0.585

 No

ref.

Severe leukopenia:

 Yes

0.953 (0.670–1.356)

 No

ref.

 Not in analysis (mild leukopenia)

PCI-score:

 0–8

ref.

ref.

 9–15

1.664 (1.310–2.115)

1.452 (1.096–1.922)

0.09

 > 15

1.609 (1.242–2.084)

1.497 (1.093–2.050)

0.012

pN-stage:

 N0

ref.

ref.

 N1

1.961 (1.421–2.704)

1.908 (1.300-2.799)

< 0.001

 N2

2.285 (1.672–3.123)

2.523 (1.743–3.653)

< 0.001

 Nx

Period of surgery:

 2019–2021

ref.

ref.

 2016–2018

0.881 (0.698–1.112)

0.906 (0.678–1.210)

0.504

 2013–2015

0.726 (0.542–0.972)

0.680 (0.478–0.969)

0.033

 ≤ 2012

0.515 (0.262–1.112)

0.282 (0.111–0.714)

0.008