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Table 4 Risk of mortality within 3 years* estimated by Cox proportional hazard ratio model

From: Postoperative leukopenia after cytoreductive surgery and hypertherm intraperitoneal chemotherapy for colorectal carcinomatosis– causes and implication on outcomes in a population-based study

 

Missing

In analysis,

Univariate analysis

p-value

Multivariate analysis

p-value

 

data, n

n

HR (95% CI)

 

HR (95% CI)

 

Age:

43

     

 < 65 years

 

299

ref.

   

 ≥ 65 years

 

242

1.037 (0.773–1.391)

0.809

  

Sex:

42

     

 Male

 

249

1.043 (0.777–1.399)

0.78

  

 Female

 

293

ref.

   

Neoadjuvant chemo:

164

     

 Yes

 

127

1.376 (0.978–1.934)

0.067

1.815 (1.059–3.110)

0.03

 No

 

293

ref.

   

Any complication :

48

     

 Yes

 

311

1.663 (1.205–2.295)

0,002

  

 No

 

225

ref.

   

Severe complication :

33

     

 Yes

 

72

2.112 (1.373–3.249)

< 0.001

2.390 (1.385–4.127)

0.002

 No

 

225

ref.

   

 Not in analysis (CD 1-3a)

 

254

    

Duration of surgery:

60

     

 < 480 min

 

267

ref.

   

 ≥ 480 min

 

257

1.313 (0.975–1.769)

0.073

0.652 (0.382–1.113)

0.117

Postop leukopenia:

40

     

 Yes

 

47

0.877 (0.508–1.514)

0.638

  

 No

 

497

ref.

   

Severe leukopenia:

38

     

 Yes

 

27

1.678 (0.934–3.015)

0.083

1.357 (0.448–4.111)

0.589

 No

 

497

ref.

   

 Not in analysis (mild leukopenia)

 

22

    

PCI-score:

45

     

 0–8

 

265

ref.

 

ref.

 

 9–15

 

159

2.084 (1.464–2.965)

< 0.001

2.318 (1.239–4.335)

0.009

 > 15

 

115

2.632 (1.822–3.801)

< 0.001

2.598 (1.313–5.141)

0.006

pN-stage:

66

     

 N0

 

107

ref.

 

ref.

 

 N1

 

181

1.902 (1.118–3.234)

0.018

0.915 (0.392–2.138)

0.837

 N2

 

227

2.991 (1.809–4.944)

< 0.001

1.844 (0.866–3.927)

0.113

 Nx

 

3

    

Period of surgery:

40

     

 2019–2021

 

201

ref.

 

ref.

 

 2016–2018

 

213

1.546 (1.070–2.234)

0.02

1.487 (0.748–2.954)

0.257

 2013–2015

 

109

1.541 (1.008–2.355)

0.046

1.019 (0.467–2.226)

0.962

 ≤ 2012

 

21

1.425 (0.669–3.034)

0.358

0.842 (0.210–3.368)

0.808

  1. * 90 day mortality excluded (n = 12)