Causal effect of gut microbiota on the risk of cancer and potential mediation by inflammatory proteins

Table 1 The mediation effect of genus Collinsella on lung cancer via T-cell surface glycoprotein CD5

Mediator	Total effect β (95%CI)	Direct effect a β(95%CI)	Direct effect b β(95%CI)	Mediation effect β (95%CI)	Mediated Proportion (%)
T-cell surface glycoprotein	-0.246(-0.463 to -0.030)	-0.174(-0.315 to -0.033)	-0.237(-0.355 to -0.119)	0.041 (0.007 to 0.086)	16.667
CD5

‘Total effect’ indicates the effect of genus Collinsella on lung cancer, ‘direct effect a’ indicates the effect of genus Collinsella on T-cell surface glycoprotein CD5, ‘direct effect b’ indicates the effect of T-cell surface glycoprotein CD5 on lung cancer and ‘mediation effect’ indicates the effect of genus Collinsella on lung cancer through T-cell surface glycoprotein CD5. Total effect, direct effect a and b were analyzed by IVW; mediation effect was analyzed by delta method

ISSN: 1477-7819