Table 2 Clinical characteristics of patients between the low and high SMI/SII groups

Age (years)*

53.3±12.1

52.8±11.3

0.622

53.5±13.3

55.4±13.5

0.241

54.4±11.9

56.8±11.1

0.039

53.6±12.3

54.6±11.8

0.105

Sex

0.050

0.050

0.778

0.596

 Male

302 (82.7)

319 (87.9)

107 (87.0)

108 (77.7)

140 (89.2)

218 (88.3)

549 (85.1)

645 (86.1)

 Female

63 (17.3)

44 (12.1)

16 (13.0)

31 (22.3)

17 (10.8)

29 (11.7)

96 (14.9)

104 (13.9)

BMI (kg/m²) #

21.9 (19.8–24.3)

22.9 (20.8–25.5)

< 0.001

22.5 (20.2–25.8)

22.9 (19.9–25.8)

0.976

22.0 (19.6–24.7)

22.7 (20.8–25.5)

0.010

21.0 (18.0-23.7)

21.9 (18.6–24.8)

< 0.001

BCLC staging (n, %)

< 0.001

0.776

-

< 0.001

 0

12 (3.3)

39 (10.7)

10 (8.1)

10 (7.2)

0

0

22 (3.4)

49 (6.5)

 A

353 (96.7)

324 (89.3)

113 (91.9)

129 (92.8)

0

0

466 (72.2)

453 (60.5)

 B

-

-

-

-

157

247

157 (24.3)

247 (33.0)

Etiologies of hepatitis (n, %)

0.034

0.646

0.032

0.006

 None

48 (13.2)

29 (8.0)

34 (27.6)

33 (23.7)

29 (18.5)

25 (10.1)

111 (17.2)

87 (11.6)

 HBV

266 (72.9)

292 (80.4)

85 (69.1)

103 (74.1)

121 (77.1)

203 (82.2)

472 (73.2)

598 (79.8)

 Others

51 (14.0)

42 (11.6)

4 (3.3)

3 (2.2)

7 (4.5)

19 (7.7)

62 (9.6)

64 (8.5)

Liver cirrhosis (n, %)

< 0.001

< 0.001

< 0.001

< 0.001

 Absence

200 (54.8)

154 (42.4)

38 (30.9)

88 (63.3)

90 (57.3)

63 (25.5)

328 (50.9)

305 (40.7)

 Presence

165 (45.2)

209 (57.6)

85 (69.1)

51 (36.7)

67 (42.7)

184 (74.5)

317 (49.1)

444 (59.3)

Tumor size (n, %)

< 0.001

0.909

< 0.001

< 0.001

 ≤ 50 mm

108 (29.6)

243 (66.9)

69 (56.1)

77 (55.4)

37 (23.6)

174 (70.4)

214 (33.2)

494 (66.0)

 > 50 mm

257 (70.4)

120 (33.1)

54 (43.9)

62 (44.6)

120 (76.4)

73 (29.6)

431 (66.8)

255 (34.0)

Number of tumors (n, %)

0.893

0.955

-

0.005

 Solitary

310 (84.9)

307 (84.6)

105 (85.4)

119 (85.6)

0

0

415 (64.3)

426 (56.9)

 Multinodular

55 (15.1)

56 (15.4)

18 (14.6)

20 (14.4)

157

247

230 (35.7)

323 (43.1)

Up-to-seven criteria (n, %)

< 0.001

0.632

< 0.001

< 0.001

 Within

142 (38.9)

276 (76.0)

77 (62.6)

83 (59.7)

33 (21.0)

163 (66.0)

252 (39.1)

522 (69.7)

 Beyond

223 (61.1)

87 (24.0)

46 (37.4)

56 (40.3)

124 (79.0)

84 (34.0)

393 (60.9)

227 (30.3)

Creatine (umol/L) #

70.2 (59.6–79.6)

72.2 (63.0-83.5)

0.006

66.0 (59.0-79.7)

66.0 (55.4–75.8)

0.110

71.8 (61.9–79.3)

72.7 (62.0-81.9)

0.582

70.1 (60.0-79.3)

71.2 (61.0–81.0)

0.098

Total bilirubin (umol/L) #

13.0 (9.3–17.6)

14.6 (11.0-19.2)

< 0.001

14.4 (10.5–20.2)

11.6 (8.7–17.1)

0.004

14.7 (11.4–21.0)

16.5 (12.6–24.2)

0.045

13.7 (10.1–19.1)

14.8 (11.0–20.0)

0.007

Albumin (g/L) #

38.6 (35.6–41.4)

38.7 (36.1–41.1)

0.662

41.5 (37.5–44.6)

40.9 (37.1–43.5)

0.126

38.3 (35.2–41.2)

37.5 (33.2–41.0)

0.148

39.0 (35.7–42.1)

38.7 (35.6–41.6)

0.197

ALBI grade (n, %)

0.698

0.845

0.698

0.508

 I

156 (42.7)

150 (41.3)

80 (65.0)

92 (66.2)

57 (36.3)

85 (34.4)

293 (45.4)

327 (43.7)

 II

209 (57.3)

213 (58.7)

43 (35.0)

47 (33.8)

100 (63.7)

162 (65.6)

352 (54.6)

422 (56.3)

Neutrophil (× 10⁹) #

4.33 (3.40–5.35)

2.64 (2.04–3.38)

< 0.001

3.51 (2.26–4.55)

3.05 (2.18–3.94)

0.103

4.36 (3.30–5.53)

2.29 (1.71–3.01)

< 0.001

4.20 (3.18–5.24)

2.60 (1.90–3.36)

< 0.001

Lymphocyte (× 10⁹) #

1.32 (1.03–1.63)

1.41 (1.06–1.84)

0.019

1.25 (0.97–1.77)

1.37 (1.05–1.86)

0.161

1.21 (0.90–1.61)

1.27 (0.92–1.70)

0.575

1.30 (1.01–1.66)

1.36 (1.02–1.80)

0.026

Platelet (× 10⁹) #

210.0 (163.0-258.5)

122.0 (86.0-159.0)

< 0.001

157.0 (101.0-215.0)

147.0 (101.0-209.0)

0.924

199.0 (154.5-250.5)

99.0 (68.0-136.0)

< 0.001

196.5 (148.9-251.1)

118.2 (81.0-159.1)

< 0.001

Monocyte (× 10⁹) #

0.38 (0.27–0.51)

0.28 (0.21–0.37)

< 0.001

0.43 (0.34–0.57)

0.46 (0.34–0.62)

0.294

0.48 (0.36–0.62)

0.33 (0.23–0.46)

< 0.001

0.41 (0.29–0.54)

0.32 (0.23–0.44)

< 0.001

SII #

623.6 (469.2-915.1)

236.9 (154.8-307.6)

< 0.001

592.3 (446.8-840.7)

203.3 (146.8-284.8)

< 0.001

659.9 (479.7-1029.5)

190.7 (120.7-252.7)

< 0.001

628.1 (466.1-931.5)

209.6 (141.0-289.0)

< 0.001

SMA (cm²) #

107.9 (88.5–124.0)

119.9 (104.3-137.2)

< 0.001

109.3 (82.9-124.8)

118.1 (102.1-137.6)

< 0.001

109.1 (85.8-125.7)

118.6 (102.3-136.6)

< 0.001

108.3 (86.2-124.7)

119.2 (103.8-136.9)

< 0.001

SMI (cm²/m²) #

38.9 (32.7–44.2)

43.6 (38.0-49.2)

< 0.001

39.2 (30.6–45.1)

43.6 (37.4–49.7)

< 0.001

40.4 (32.5–44.9)

43.2 (37.3–49.0)

< 0.001

39.1 (32.4–44.4)

43.5 (37.5–49.1)

< 0.001

AFP level (n, %)

0.011

0.121

< 0.001

< 0.001

≤ 200ng/mL

207 (56.7)

239 (65.8)

69 (56.1)

91 (65.5)

72 (45.9)

162 (65.6)

348 (54.0)

492 (65.7)

> 200ng/mL

158 (43.3)

124 (34.2)

54 (43.9)

48 (34.5)

85 (54.1)

85 (34.4)

297 (46.0)

257 (34.3)