Table 1 Research on SDC family structure
From: SDC1 is a critical transmembrane proteoglycan in breast cancer
Members | Features of intracellular variable region (C1) | Primary binding proteins | Core functional tendencies |
|---|---|---|---|
SDC1 | Short C1 region, containing PDZ binding motif (EFYA) | Src, ERM proteins (Ezrin) | Invasion, immune evasion |
SDC2 | Long C1 region, containing phosphorylation sites (Tyr/Ser) | CASK、α-actinin、FAK | Adhesion dynamics regulation, EMT |
SDC3 | Long C1 region, containing PDZ binding motif (DTKN) | Syntenin、Synbindin、PKCδ | Neuronal migration, inhibition of invasion |
SDC4 | Short C1 region, containing PDZ binding motif (EENY) | PKCα, PIP2, PDZ protein (Synectin) | Stabilizing adhesion, anti-migration |