Table 2 Research on SDC family function
From: SDC1 is a critical transmembrane proteoglycan in breast cancer
Function | SDC1 | SDC2 | SDC3 | SDC4 |
|---|---|---|---|---|
Adhesion properties | Adhesion dissociation (MMP activation) | Dynamic adhesion (Rac1-dependent) | Neurotrophically specific adhesion | Stable adhesion (RhoA activation) |
Invasive tendency | Strong promotion of invasion (EMT-driven) | Bidirectional regulation (dependent on microenvironment) | Inhibition of invasion (MMP inhibition) | Inhibition of invasion (anti-EMT) |
Core pathways | Wnt/β-catenin、PI3K/Akt | TGF-β/Smad、Rac1 | PKCδ/ERK、PDGFRβ | RhoA/ROCK、PKCα |
Prognostic association | Unfavorably poor prognosis (high metastasis) | Colon cancer has poor prognosis, lung cancer has good prognosis | Neuro-oncology has a better prognosis | Preferably good prognosis (low metastasis) |
Therapeutic target potential | Antibody targeting (such as Indatuximab) | Inhibition of TGF-β pathway | Recovery of expression (gene therapy) | Enhance adhesion (anti-metastasis) |